The sudden appearance of monkeypox outside its endemic regions, in Central and West Africa, surprised the world. Although it was not the first time the virus had broken out elsewhere, the scale of the current health crisis is unprecedented. From the beginning of May to the middle of July, at least 7,665 cases have been reported in the European Union (EU), according to figures compiled by Civio, which is one thousand more cases than the WHO reports. It is the largest outbreak of this virus ever seen in Europe, where few countries were well-prepared.
“No one expected transmission within Europe or the United States, without [a patient] having travelled or their partner or friend having travelled,” says Mar Faraco, president of the Spanish Association of Foreign Health Doctors. For the moment, the most affected countries in the EU are Spain (2,895 cases), Germany (1,859), France (912), the Netherlands (549), and Portugal (515), while the United Kingdom, where the first patients of this outbreak were detected, reported 1,856 cases through mid-July.
Two different, but related, poxes
Monkeypox is caused by a virus similar to the smallpox virus, which the WHO certified eradicated in 1979. However, while smallpox has accompanied our species for centuries, researchers first confirmed transmission of monkeypox among humans in 1970. Since then, this monkeypox has gained ground, although without the tragic consequences of smallpox. “The smallpox virus had a 30%, mortality rate and decimated entire populations,” says Esteban, while the monkeypox mortality rate is between 1% and 10%. According to an initial analysis by researchers at the Carlos III Health Institute, the current outbreak seems to be caused by the less virulent variant.
“[That] cases like this occur, which are appearing in different countries, is very striking,” says virologist Mariano Esteban, of the National Centre for Biotechnology (CNB-CSIC). However, he says the situation “is very different” from the beginning of the COVID-19 pandemic, since there are diagnostic tests, antiviral drugs such as Tecovirimat and, especially, vaccines. However, monkeypox has for years been a neglected disease that affected Africa the most, which explains why many European countries lacked adequate means to control this outbreak.
A vaccine as in-demand as it is limited
The majority of detected cases in this outbreak “have presented with mild to moderate symptoms” and patients generally recover after several weeks. However, to prevent the spread of the disease and to mitigate its severity, European authorities first proposed vaccinating close contacts of a confirmed case within the first four days. In early July, the European Centre for Disease Control and Prevention recommended also vaccinating the most at-risk groups - certain groups of men who have sex with men and health care workers.
However, this will be difficult to achieve due to the scarcity of vaccines. One of the options is Imvanex, a third-generation vaccine, which was authorised in Europe against smallpox and, in the United States, where it is called Jynneos, is also authorised for monkeypox. This shot has far fewer side effects than previous vaccines, which explains why Imvanex is the most coveted vaccine.
But there’s a problem: it is only manufactured by a small pharmaceutical company called Bavarian Nordic, which means there is limited availability. Germany ordered 40,000 vaccines in June and 200,000 more for delivery through the end of the year. The European Commission, through the newly created European Authority for Preparedness and Response to Health Emergencies (HERA), purchased emergency 163,620 doses. Civio has asked EU and national authorities about the unit price they paid for Imvanex, without receiving an answer.
|📍 Country||💉 Doses of requested vaccines||💶 Joint purchase?|
|Belgium||33,040||Yes (only 3,040 through HERA and 30,000 doses are received through direct national purchase)|
|Czechia||Under deliberation||Under deliberation|
|Luxembourg||Small but unconfirmed number||Yes|
|Spain||10,200-12,200||Yes (10,000 - 12,000 through HERA and 200 doses through direct national purchase)|
In Europe, the formula is similar to the one adopted with the COVID-19 pandemic (a joint purchase to secure the supply), although with one exception: this time the payment is via EU funds. Several EU countries told Civio they have requested vaccines from HERA, which prioritises distribution according to the impact of the virus. Thus, for example, Spain, one of the most affected countries, has already announced receipt of 5,300 doses, almost half of the vaccines it has ordered so far.
The belated solution - the first doses arrived weeks after the outbreak began -will alleviate the lack of Imvanex vaccines in many European countries. “Vaccination against monkeypox will be limited to very specific cases, since the transmissibility and risk of the virus are not comparable to COVID,” says Stefan De Keersmaecker, spokesperson for the health area of the European Commission.
Varied but insufficient preparation
Only the Netherlands and France report having had strategic stockpiles of Imvanex vaccines prior to the outbreak. A spokesman for the Dutch Ministry of Health points out that, in 2019, when monkeypox did not seem like a direct threat, they bought 100,000 doses of Imvanex, almost as many as those now acquired by the EU. The Netherlands has since sold a small number of these vaccines to Denmark and Spain, which had none. French authorities also confirm that their national reserve has doses of Imvanex, along with other first- and second-generation vaccines. Their availability, they explain, is part of the government’s “plan to respond to the risk of the recurrence of smallpox.”
Both countries’ strategies are similar to that of the United States, although with much smaller quantities: in 2012, the Obama administration bought twenty million doses for its national reserve, which this year has expanded with half a million more. Risk planners have always feared that the smallpox, not monkeypox, could be used in a bioterrorist attack. These fears increased after the September 11 attacks, and rose again during one of the first large outbreaks of monkeypox outside Africa, which in 2003 caused 47 confirmed or probable cases in the United States.
These dangers led many countries to include smallpox vaccines in their strategic stockpiles, even if they did not include later generation vaccines such as those of Imvanex. That was the case in Spain, Belgium, Poland, Portugal or Slovakia, whose reserves in some cases include second-generation vaccines such as ACCAM 2000. In Germany and Italy, there are also stocks, but the authorities do not specify the type of vaccine. This lack of transparency is greatest in Ireland, Luxembourg, and Sweden, where the information is confidential for national security reasons.
|📍 Country||🔒 National strategic reserve||💉 Type of vaccine available|
|Belgium||Yes||Second generation vaccines (ACCAM 2000)|
|France||Yes||First, second and third generation vaccines (including Imvanex)|
|Italy||Yes||5 million unspecified doses|
|The Netherlands||Yes||First and third generation vaccines (including Imvanex)|
|Poland||Yes||Second generation vaccines (ACCAM 2000)|
|Portugal||Yes||First generation vaccines|
|Romania||No info available||No info available|
|Spain||Yes||2 million second-generation doses (ACCAM 2000)|
At the other end of Europe are Bulgaria, Cyprus, the Czech Republic, Estonia, Latvia, Slovakia, and Slovenia, which report that they did not stockpile smallpox vaccines. In contrast, the World Health Organization (WHO) holds an emergency reserve of 2.4 million doses in Geneva and another 31 million vaccines stored in France, Germany, New Zealand, the United Kingdom, and the United States. Its stockpile includes Imvanex units and first- and second-generation vaccines, although, for the moment, the WHO does not know how much there is of each, says Sylvie Brand, WHO director of preparedness for global risks of infectious origin.
A prophecy fulfilled
This monkeypox outbreak was a surprise, but it was by no means unexpected. Public health workers feared that when smallpox was eradicated and mass immunisation campaigns ended, similar viruses would infect people who lacked protection. In fact, an observational study conducted in the 1980s in present-day Democratic Republic of the Congo estimated that smallpox vaccination offered 85% protection against monkeypox. However, when smallpox disappeared, the WHO recommended countries stop immunising due to the vaccines’ side effects and the significant costs of immunisation programmes.
However, the same study also warned that: “The average magnitude and duration of monkeypox epidemics will increase as vaccine-derived protection decreases in the population.” That first warning didn’t fall on deaf ears. Another study, published in 2012 in the journal PNAS, and a recent systematic review in PLOS Neglected Tropical Diseases also voiced growing concern about a potential increase in cases of monkeypox. Those prophecies have finally been fulfilled.
“It is a disease in which older people will be better protected than younger people.”
In Europe, where most countries stopped vaccinating against monkeypox between the 1970s and 1980s, a large number of people are now vulnerable to the virus. “The population is susceptible; most of them are under the age of 50. And that means they are a great host for the virus, with no resistance whatsoever,” says virologist Mariano Esteban. “It is the opposite of the usual case,” Faraco says, “It is a disease in which older people will be better protected than younger people.”
|📍 Country||❌ End of vaccination against smallpox||📂 Source|
|Austria||1977||Wiener klinische Wochenschrift|
|Belgium||1976||FPS Public Health|
|Bulgaria||1980||Ministry of Health|
|Cyprus||1975||Ministry of Health|
|Czechia||1980||Ministry of Health|
|Finland||1980||Finnish Institute for Health and Welfare|
|France||1978||Ministry of Health|
|Germany||1976 (Western), 1982 (Eastern)||Federal Ministry of Health|
|Ireland||1972||National Vaccination Office|
|Italy||1976||Journal of General Virology|
|Latvia||1980||Ministry of Health|
|Luxembourg||1976||Ministry of Health|
|The Netherlands||1974||Ministry of Health, Welfare and Sport|
|Poland||1980||Ministry of Health|
|Portugal||1977||Faculty of Medicine of the University of Lisbon|
|Romania||1977||Ministry of Health|
|Slovakia||1980||Ministry of Health|
|Slovenia||1983||National Institute of Public Health|
|Spain||1980||Ministry of Health|
|Sweden||1976||Ministry of Health and Social Affairs|
Data published by the European Centre for Disease Prevention and Control (ECDC) confirm this pattern. Of the 6,776 cases analysed up to the middle of July, 89.51%% were under 50 years old. “That implies that those of us who are vaccinated against smallpox must be protected, but we don’t know that for sure yet,” Esteban explains. The reason is that the old vaccines were “very good, with significant side effects, but they eradicated smallpox,” Faraco says. Although no one has faced a real outbreak of smallpox since, health care workers hope that the vaccines will continue to provide long-lasting immunity.
Africa is, as always, the forgotten land
The outbreak caused by this forgotten virus also offers another important lesson. For years, monkeypox seemed to affect only the African countries where it is most frequently transmitted, such as the Democratic Republic of the Congo, Nigeria or Cameroon. “It is important to help in the territories where these pathogens are found, improving prophylactic measures, looking for vaccines and effective treatments,” says Jacob Lorenzo-Morales, professor of Parasitology at the University of La Laguna and director of the University Institute of Tropical Diseases and Public Health of the Canary Islands, in statements to the Science Media Centre España.
“When it jumps to the most advanced countries it provokes a social alarm, the result of the panic of society, which thinks that viruses happen to others, that they are in the jungle or in other environments, and that we are exempt from it,” Esteban says. Since 2022, the Centres for Disease Control and Prevention in Africa has documented 1,715 cases, among suspected and confirmed patients, and 73 deaths from this virus. “Except when [an infected] traveller has left those countries, no one has cared about cases there,” Faraco says. The best strategy would be to monitor monkeypox where it remains endemic, which would help curb infections and deaths in those places, and prevent its impact on other regions, he says: “It would probably fix a lot of the outbreaks, but it hasn’t been done.”
In the report, David Cabo contributed to the review of public procurement data. In addition, this work is the result of an EDJNET investigation involving journalists from four countries of the EU. Danuta Pawłowska of the Gazeta Wyborcza reviewed Polish data; Alessandro Follis of Euractiv Italy reviewed Italian data; Neja Berger of Pod črto reviewed Slovenian data; and Tiago Ramalho of Public reviewed Portuguese data.
We contacted national public health authorities in all EU member states to request the date when each country stopped immunising against smallpox and when this type of vaccination was no longer compulsory to travel there. Since at that time some current EU countries were part of the USSR, we asked the authorities about the situation of the territory that makes up their country today. In Austria, Italy, and Portugal, the information comes from various specialised sources, and we did not find data for Croatia, Greece, Hungary, Lithuania, and Malta.
We also asked whether, prior to the current health crisis, strategic stocks of smallpox vaccines were available and the number of doses and the type of vaccine. The health authorities of Austria, Croatia, Denmark, Finland, Greece, Hungary, Lithuania, and Malta did not reply to multiple requests.
In addition, we contacted the press offices of the European Commission, Bavarian Nordic and the World Health Organization (WHO) to learn more about the joint purchase of vaccines and the strategic storage of smallpox vaccines for emergencies. We also asked the EU countries about the number of doses requested through HERA procurement and the immunisation protocols established to control the current outbreak. We searched the Public Procurement Portal in Spain and asked the Ministry of Health about the 200 vaccines purchased at the beginning of June, prior to the arrival of Imvanex units through HERA, but we have not received an answer. No European or national authority has shared the unit price of vaccines, citing confidentiality agreements with Bavarian Nordic.
Finally, we compiled case data published by the World Health Organisation through the dissemination of Disease Outbreak News (DONs) and looked at the data regularly released by the European Centre for Disease Control and Prevention.
Since national authorities update their figures more often, the cases collected by Civio originate in most countries from state institutions (Austria, Bulgaria, France, Germany, Ireland, Italy, Latvia, Luxembourg, The Netherlands, Portugal, Romania, Slovakia, Slovenia, Sweden, and the United Kingdom), except in those countries that do not publish their epidemiological statistics or bulletins or where their data are outdated, in which case the information comes from the WHO, which provides the most up-to-date figures.
The data do not have the same frequency and date of publication, so they are not directly comparable. You can download the data here.